Figure 1.
Log10 P values for the association of 106 single nucleotide polymorphisms (SNPs) in REN, HSD11B1, AGT, AGTR1, NR3C2, CYP11B2, ACE, AGTR2, and RENBP with longitudinal changes in systolic and diastolic blood pressure, as well as hypertension incidence. The black and white circles show P values for the testing of genotype by follow-up time interactions for systolic blood pressure and diastolic blood pressure, respectively, while the gray circles show P values for the testing of the effect of SNPs on hypertension incidence. Two labeled SNPs were significantly associated with longitudinal changes in systolic BP after using false discovery rate procedures for multiple testing.