Table 2.
Association of significant RAAS SNPs with BP changes and hypertension incidence among GenSalt study participants
| HGNC gene symbol | SNP | Chr. | Position | Genotype | Systolic BP change | Diastolic BP change | HTN incidence | |||
|---|---|---|---|---|---|---|---|---|---|---|
| β (SE) | P valuea | β (SE) | P valuea | OR (95% CI) | P valueb | |||||
| NR3C2 | rs7694064 | 4 | 149302668 | A/A (195) | 2.26 (0.16) | 6.9×10–5c | 1.33 (0.11) | 0.08 | 1.33 (0.93, 1.89) | 0.30 |
| G/A (828) | 1.76 (0.07) | 1.23 (0.05) | 1.00 (0.78, 1.28) | |||||||
| G/G (856) | 1.56 (0.07) | 1.15 (0.05) | Ref. | |||||||
| rs6856803 | 4 | 149306577 | C/C (415) | 1.51 (0.10) | 8.2×10–4c | 1.08 (0.07) | 0.08 | 0.83 (0.60, 1.14) | 0.19 | |
| T/C (918) | 1.66 (0.07) | 1.21 (0.05) | 0.75 (0.57, 0.99) | |||||||
| T/T (548) | 1.97 (0.10) | 1.28 (0.07) | Ref. | |||||||
Abbreviations: BP, blood pressure; Chr. = chromosome; HGNC = HUGO gene nomenclature committee; HTN = hypertension; OR = odds ratio; RAAS = renin–angiotensin–aldosterone system; SNP = single nucleotide polymorphism.
a P value for genotype × time interaction term.
b P value for additive genetic association.
cSignificant after adjustment for multiple testing.