Table 3.
Associations of 8 RAAS genes containing at least 2 SNPs with longitudinal BP phenotypes in the GenSalt study
| HGNC symbol | k | Systolic BP change | Diastolic BP change | HTN incidence |
|---|---|---|---|---|
| REN | 7 | 0.31 | 0.46 | 0.36 |
| HSD11B1 | 12 | 0.48 | 0.47 | 0.79 |
| AGT | 7 | 0.07 | 0.28 | 0.01 |
| AGTR1 | 10 | 0.53 | 0.25 | 0.42 |
| NR3C2 | 57 | 1.00×10−7a,b,c | 0.61 | 1.00 |
| CYP11B1 | 3 | 0.18 | 0.25 | 0.05 |
| CYP11B2 | 3 | 0.17 | 0.17 | 0.26 |
| ACE | 5 | 0.31 | 0.45 | 0.46 |
Abbreviations: BP = blood pressure; HGNC = HUGO gene nomenclature committee; HTN = hypertension; k = number of SNPs included in gene-based analyses; RAAS = renin–angiotensin–aldosterone system; SNP = single nucleotide polymorphism.
aSignificant after adjustment for multiple testing.
bSignificant after simultaneous removal of significant SNPs from gene-based analyses.
cEvidence of replication in the Multi-ethnic Study of Atherosclerosis (P = 1.00×10−4 for NR3C2 – systolic BP change association).