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. 2015 Oct 9;149(1):178–191. doi: 10.1093/toxsci/kfv224

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Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US.

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FIG. 5. — DPeP-induced gross malformations in several androgen-dependent tissues (examined at necropsy) in F1 males. The percent affected for each effect is shown on the Y-axes graphed with dose and the percent reductions in fetal testosterone production (T PROD), PT and testis testosterone on the X-axes (except undescended testes and gubernacular agenesis). The incidence of undescended testes and gubernacular agenesis are also graphed with DPeP dose and percent of control Insl3 mRNA levels on the X-axis since normal development of the fetal gubernacular cord is dependent upon the Insl3 peptide hormone.

FIG. 5. — DPeP-induced gross malformations in several androgen-dependent tissues (examined at necropsy) in F1 males. The percent affected for each effect is shown on the Y-axes graphed with dose and the percent reductions in fetal testosterone production (T PROD), PT and testis testosterone on the X-axes (except undescended testes and gubernacular agenesis). The incidence of undescended testes and gubernacular agenesis are also graphed with DPeP dose and percent of control Insl3 mRNA levels on the X-axis since normal development of the fetal gubernacular cord is dependent upon the Insl3 peptide hormone.