TABLE 1.
Maternal, Fetal and Neonatal Effects of Gestational Administration of Dipentyl Phthalate (DPeP)
| Dose mg/kg/day | 0 | 11 | 33 | 100 | 300 | F value |
|---|---|---|---|---|---|---|
| Maternal and fetal effects of administration of DPeP on days 14–18 of pregnancy | ||||||
| Number of litters | 8 | 9 | 7 | 9 | 9 | |
| Maternal weight GD 18 | 333 ± 8.7 | 328 ± 8.6 | 339 ± 8.5 | 337 ± 7.9 | 321 ± 6.9 | NS |
| Maternal weight gain GD 18 | 49.5 ± 5.2 | 43.6 ± 4.0 | 47.3 ± 2.9 | 49.6 ± 2.3 | 37.9 ± 4.7* | NS |
| Number fetuses | 12.8 ± 1.3 | 9.2 ± 1.7 | 12.4 ± 1.2 | 12.3 ± 0.7 | 10.0 ± 1.5 | NS |
| Number resorbed | 0 ± 0 | 1.8 ± 1.7 | 0.14 ± 0.14 | 0.33 ± 0.17 | 1.0 ± 0.9 | NS |
| Number dead | 0.12 ± 0.12 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | NS |
| Maternal and neonatal effects of administration of DPeP on days 8–18 of pregnancy | ||||||
| Number of litters | 5 | 5 | 5 | 5 | 5 | |
| Maternal weight (g) GD 18 | 318.2 ± 12.9 | 317.6 ± 5.5 | 304.3 ± 5.5 | 323.1 ± 4.4 | 306.7 ± 7.6 | NS |
| Maternal weight gain (g) GD 8–18 | 74.9 ± 4.4 | 74.7 ± 4.5 | 69.9 ± 5.1 | 72.7 ± 1.5 | 55.1 ± 4.4 ** | p < 0.02 |
| % Pup Survival to 2 days of agea | 94.4 ± 3.4 | 87.2 ± 3.1 | 80.2 ± 7.5 | 67.2 ± 8.0* | 48.4 ± 15.4** | p < 0.02 |
| Male AGD (mm) at 2 days of agea | 3.73 ± 0.07 | 3.59 ± 0.08 | 3.67 ± 0.13 | 3.32 ± 0.14* | 2.7 ± 0.04** | p < 0.0001 |
| Male body weight (g) at 2 days of agea | 7.77 ± 0.11 | 8.04 ± 0.18 | 8.02 ± 0.40 | 7.54 ± 0.56 | 6.94 ± 0.31 | NS |
| Female AGD (mm) at 2 days of age | 1.75 ± 0.07 | 1.83 ± 0.06 | 1.90 ± 0.07 | 1.75 ± 0.04 | 1.74 ± 0.13 | NS |
| Female body weight (g) at 2 days of age | 7.30 ± 0.09 | 7.60 ± 0.20 | 7.60 ± 0.30 | 7.28 ± 0.49 | 6.50 ± 0.20 | NS |
Values are means ± Standard errors; *P < .05, **P < .01 different from control by t test
aOriginally reported by Hannas et al. (2011a).
Survival = (100 − mortality); mortality = (implants − number of live 2-day-old pups).