TABLE 2.
In Utero Exposure to DPeP Induces Gross Abnormalities in the Reproductive and Urogenital Tracts of the Male Rat Offspring
| DPeP dose mg/kg/d | 0.0 | 11.0 | 33.0 | 100.0 | 300.0 |
| Number of litters | 5.0 | 5.0 | 5.0 | 4.0 | 4.0 |
| Number of males examined | 30.0 | 23.0 | 18.0 | 14.0 | 13.0 |
| Percent (number) of individual F1 male rats affected | |||||
| Retained nipples | 0 | 0 | 0 | 14.3 (2) | 69.2 (9) |
| Hypospadias | 0 | 0 | 0 | 0 | 53.8 (7) |
| Agenesis of vas deferns | 0 | 0 | 0 | 0 | 92.3 (12) |
| Small ventral prostate | 0 | 0 | 0 | 0 | 15.4 (2) |
| Agenesis or abnormal seminal vesicle | 0 | 0 | 0 | 0 | 69.2 (9) |
| Abnormal testis | 0 | 0 | 5.6 (1) | 7.1 (1) | 100 (13) |
| Agenesis of epididymis | 0 | 0 | 0 | 7.1 (1) | 92.3 (12) |
| Agenesis or elongated gubernaculums | 0 | 0 | 0 | 35.7 (5) | 100 (13) |
| Undescended testis | 0 | 0 | 0 | 7.1 (1) | 100 (13) |
| Phthalate syndrome | 0 | 0 | 5.6 (1) | 42.8 (6) | 100 (13) |
| Hydronephrosis | 0 | 4.3 (1) | 5.6 (1) | 14.3 (2) | 53.8 (7) |
The table presents the percentage of F1 males (on an individual rather than a litter basis), displaying gross reproductive and kidney abnormalities following in utero exposure to DPeP. In contrast to the data in this table, the figures in this study display litter mean values for the malformations. In the 2 high DPeP dose groups, males often displayed more than one malformation per male.