TABLE 3.
Adult F1 Male Rat Necropsy
| DPeP dose (mg/kg/day) |
|||||
|---|---|---|---|---|---|
| 0 | 11 | 33 | 100 | 300 | |
| Body weight (g) | |||||
| Mean | 487.6 | 472.5 | 481.0 | 493.5 | 405.5 |
| SE | 11.64 | 14.04 | 13.03 | 20.75 | 5.98 |
| N | 5 | 5 | 5 | 4 | 4 |
| Liver weight (g) | |||||
| Mean | 16.5 | 16.0 | 16.4 | 16.3 | 13.1 |
| SE | 0.61 | 0.91 | 0.28 | 0.82 | 0.76 |
| N | 5 | 5 | 5 | 4 | 4 |
| Cowper’s glands (mg) | |||||
| Mean | 102.6 | 96.2 | 99.8 | 109.2 | 89.2 |
| SE | 5.47 | 5.74 | 4.04 | 4.92 | 11.52 |
| N | 5 | 5 | 5 | 4 | 4 |
| Glans penis (mg) | |||||
| Mean | 103.1 | 105.5 | 103.1 | 103.2 | 87.9 |
| SE | 1.46 | 2.16 | 1.74 | 2.93 | 6.54 |
| N | 5 | 5 | 5 | 4 | 2 |
| Levator–ani-bulbocavernosus muscles (g) | |||||
| Mean | 1.15 | 1.11 | 1.09 | 1.07 | 0.45 |
| SE | 0.036 | 0.064 | 0.017 | 0.051 | 0.104 |
| N | 5 | 5 | 5 | 4 | 4 |
| Seminal vesicle (g) | |||||
| Mean | 1.73 | 1.62 | 1.68 | 1.60 | 0.64 |
| SE | 0.081 | 0.065 | 0.047 | 0.116 | 0.282 |
| N | 5 | 5 | 5 | 4 | 4 |
| Caput corpus epididymis (mg) | |||||
| Mean | 0.35 | 0.34 | 0.34 | 0.34 | 0.01 |
| SE | 0.010 | 0.007 | 0.010 | 0.036 | 0.013 |
| N | 5 | 5 | 5 | 4 | 4 |
| Cauda epididymis (mg) | |||||
| Mean | 0.262 | 0.255 | 0.241 | 0.226 | 0.016 |
| SE | 0.009 | 0.005 | 0.004 | 0.024 | 0.016 |
| N | 5 | 5 | 5 | 4 | 4 |
| Paired testes (g) | |||||
| Mean | 4.42 | 4.04 | 3.90 | 4.05 | 1.13 |
| SE | 0.44 | 0.11 | 0.19 | 0.39 | 0.09 |
| N | 5 | 5 | 5 | 4 | 4 |
| Ventral prostate (mg) | |||||
| Mean | 691.2 | 626.1 | 705.1 | 659.0 | 442.5 |
| SE | 32.80 | 42.53 | 47.82 | 68.72 | 68.90 |
| N | 5 | 5 | 5 | 4 | 4 |
| Left gubernacular cord (mm) | |||||
| Mean | 9.31 | 9.37 | 10.04 | 10.25 | |
| SE | 0.37 | 0.28 | 0.54 | 0.77 | |
| N | 5 | 5 | 5 | 4 | 0 A |
| Right gubernacular cord (mm) | |||||
| Mean | 9.89 | 10.88 | 10.77 | 14.41 | |
| SE | 0.37 | 0.17 | 0.43 | 3.43 | |
| N | 5 | 5 | 5 | 4 | 0 A |
Shaded values in bold indicate values that differ significantly from control at the P < .01 level. n refers to the numbers of litters. “A” indicates that none of the males in the high-dose group had a gubernacular cord.