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. Author manuscript; available in PMC: 2017 Jan 12.
Published in final edited form as: Cell Metab. 2016 Jan 12;23(1):27–47. doi: 10.1016/j.cmet.2015.12.006

Figure 2. Deregulated uptake of glucose and amino acids.

Figure 2

Aberrantly activated oncogenes and loss of tumor suppressors deregulates the import of glucose and amino acids into cancer cells. Solid arrows depict the movement of metabolites or proteins and metabolic reactions. Dashed arrows depict positive and negative regulatory effects of signal transduction components. RTK, receptor tyrosine kinase; GLUT1, glucose transporter 1; ASCT2/SN2, glutamine transporter; LAT1, neutral amino acid transporter; EAA, essential amino acids; GLS1, glutaminase 1; PRPS2, phosphoribosyl pyrophosphate synthetase 2; CAD, carbamoyl-phosphate synthetase 2; HK, hexokinase; ECM, extracellular matrix.