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. Author manuscript; available in PMC: 2017 Jan 12.
Published in final edited form as: Cell Metab. 2016 Jan 12;23(1):27–47. doi: 10.1016/j.cmet.2015.12.006

Figure 5. Increased demand for nitrogen.

Figure 5

Sources of nitrogen atoms and regulation of nucleotide and polyamine biosynthesis. PRPP, phosphoribosyl pyrophosphate; PRPS2, phosphoribosyl pyrophosphate synthetase 2; CAD, carbamoyl-phosphate synthetase 2; Gln, glutamine, Glu, glutamate; Gly, glycine; Asp, aspartate; Fum, fumarate; IMPDH1/2, inosine-5-monophosphate dehydrogenase; TS, thymidylate synthase; GMPS, guanosine monophosphate synthetase; DCK, deoxycytidine kinase; TK, thymidine kinase, ARG1, arginase 1; ODC, ornithine decarboxylase; CAT1/2, cationic amino acid transporter.