Zheng 2005.
| Methods |
Study design: parallel‐group randomized controlled trial (20 participants both eyes included) Number randomized: 48 eyes of 28 participants total; 24 eyes in each group Exclusions after randomization: not reported Losses to follow‐up: not reported Unit of analysis: eye Number analyzed: not reported How were missing data handled?: not reported Power calculation: not reported |
|
| Participants |
Country: China Age: not reported Gender: not reported Inclusion criteria: not reported; all participants were diagnosed primary angle‐closure glaucoma or primary open‐angle glaucoma Exclusion criteria: not specified Equivalence of baseline characteristics: yes |
|
| Interventions |
Intervention 1: trabeculectomy + AMT Intervention 2: trabeculectomy + MMC Length of follow‐up: Planned: not reported Actual: 12 months |
|
| Outcomes | Primary and secondary outcomes not distinguished Outcomes, as reported: filtering bleb, surgical success, IOP, visual acuity, and complications Intervals at which outcomes assessed: 1 day, 1 week, and 1, 3, and 6 months |
|
| Notes |
Publication type: published article Funding sources: not reported Disclosures of interest: not reported Trial registry: not registered Study period: not reported Subgroup analyses: none reported Publication language: Chinese Authors contacted in regards to number with missing data at different follow‐up time points, but no response received |
|
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Random sequence generation was not reported |
| Allocation concealment (selection bias) | Unclear risk | Allocation concealment was not reported |
| Masking of participants and personnel (performance bias) | Unclear risk | Masking of participants and personnel was not reported |
| Masking of outcome assessment (detection bias) | High risk | Not reported. Although it is not possible to mask outcome assessors, devices can be easily seen during examination of the eye |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | The number of participants with missing or incomplete outcome assessment was not reported |
| Selective reporting (reporting bias) | High risk | Protocol was not available. Surgical success reported in the Results section was not mentioned in the Methods section |
| Other bias | Unclear risk | Did not report source of funding or conflict of interest. This article provided nothing on study design; we contacted the authors but did not receive a response |
5‐FU: 5‐fluorouracil ACG: angle‐closure glaucoma BCVA: best‐corrected visual acuity AMT: amniotic membrane E‐PTFE: expanded polytetrafluoroethylene IOP: intraocular pressure MMC: mitomycin C OAG: open‐angle glaucoma PACG: primary angle‐closure glaucoma PEXG: pseudoexfoliation glaucoma POAG: primary open‐angle glaucoma VA: visual acuity