Table 1.
Baseline patients' characteristics used in the discovery phase
| N (n = 5) | dnHA (n = 5) | MHA (n = 5) | P value | |
|---|---|---|---|---|
| Age (years) | 58 ± 7 | 58 ± 7 | 62 ± 5 | 0.463 |
| Sex (male), % | 60 | 60 | 60 | >0.999 |
| BMI (kg/m2) | 30 ± 3 | 29 ± 1 | 28 ± 4 | 0.650 |
| Current smoking, % | 0 | 40 | 20 | 0.725 |
| Total cholesterol (mg/dl) | 188 ± 32 | 157 ± 15 | 175 ± 18 | 0.159 |
| Triglycerides (mg/dl) | 114 ± 43 | 112 ± 68 | 90 ± 27 | 0.765 |
| HDL cholesterol (mg/dl) | 49 ± 12 | 51 ± 23 | 58 ± 12 | 0.497 |
| LDL cholesterol (mg/dl) | 116 ± 34 | 83 ± 13 | 99 ± 12 | 0.150 |
| Glycaemic (mg/dl) | 91 ± 11 | 101 ± 7 | 92 ± 8 | 0.190 |
| Uric acid (mg/dl) | 5.6 ± 1.7 | 6.1 ± 1.8 | 4.6 ± 1.2 | 0.330 |
| Creatinine clearance rate (mg/ml) | 87 ± 24 | 112 ± 61 | 89 ± 28 | 0.876 |
| eGFR (ml/min/1.73 m2) | 83 ± 10 | 87 ± 28 | 88 ± 17 | 0.536 |
| Systolic blood pressure (mmHg) | 132 ± 16 | 138 ± 8 | 126 ± 15 | 0.390 |
| Diastolic blood pressure (mmHg) | 84 ± 14 | 83 ± 10 | 81 ± 7 | 0.869 |
| ACR (mg/g) | 3.8 ± 1.7 | 74 ± 33 | 75 ± 90 | 0.001 |
| Diabetes mellitus, % | 0 | 0 | 0 | >0.999 |
Values expressed as mean ± SD or percentages (%)
BMI body mass index, HDL high-density lipoprotein cholesterol, LDL low-density lipoprotein cholesterol, N normoalbuminuria, dnHA de novo high albuminuria, MHA maintained high albuminuria