Table 2.
Baseline patients' characteristics used as confirmation cohort
| N (n = 47) | dnHA (n = 20) | MHA (n = 23) | P value | |
|---|---|---|---|---|
| Age (years) | 65 ± 11 | 69 ± 7 | 65 ± 12 | 0.382 |
| Sex (male), % | 34 | 70 | 61 | 0.012 |
| BMI (kg/m2) | 31 ± 5 | 30 ± 4 | 31 ± 5 | 0.796 |
| Current smoking, % | 13 | 15 | 13 | 0.969 |
| Total cholesterol (mg/dl) | 186 ± 29 | 166 ± 27 | 170 ± 31 | 0.035 |
| Triglycerides (mg/dl) | 119 ± 53 | 130 ± 70 | 139 ± 74 | 0.488 |
| HDL cholesterol (mg/dl) | 56 ± 13 | 51 ± 9 | 44 ± 12 | 0.0003 |
| LDL cholesterol (mg/dl) | 106 ± 28 | 90 ± 19 | 100 ± 24 | 0.088 |
| Glycaemic (mg/dl) | 118 ± 42 | 123 ± 26 | 119 ± 34 | 0.387 |
| Uric acid (mg/dl) | 4.9 ± 1.5 | 6.3 ± 1.5 | 6.9 ± 1.7 | <0.0001 |
| Creatinine clearance rate (mg/ml) | 101 ± 40 | 97 ± 47 | 76 ± 41 | 0.138 |
| eGFR (ml/min/1.73 m2) | 81 ± 18 | 68 ± 19 | 64 ± 29 | 0.024 |
| Systolic blood pressure (mmHg) | 138 ± 18 | 139 ± 22 | 140 ± 28 | 0.975 |
| Diastolic blood pressure (mmHg) | 81 ± 11 | 81 ± 11 | 82 ± 17 | 0.993 |
| ACR (mg/g) | 11 ± 13 | 211 ± 388 | 662 ± 910 | <0.0001 |
| Diabetes mellitus, % | 32 | 60 | 52 | 0.066 |
Values expressed as mean ± SD or percentages (%)
BMI body mass index, HDL high-density lipoprotein cholesterol, LDL low-density lipoprotein cholesterol, N normoalbuminuria, dnHA de novo high albuminuria, MHA maintained high albuminuria