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. 2016 Jan 16;14:6. doi: 10.1186/s12951-016-0157-1

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© Chaudhary et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Enhancement in MRI/CT contrast and internalisation efficacy of nanoparticles. a Slight enhancement of T1 MRI contrast was observed in Hsp-70 Lf-PEG-ZF compared to ferrite nanoparticles. b Significant enhancement of T2 MRI contrast was observed in Hsp-70 Lf-PEG-ZF compared to ferrite nanoparticles. c Slight enhancement of CT contrast was observed in Hsp-70 Lf-PEG-ZF compared to ferrite nanoparticles. d Confocal microscopy internalization images and cell cytometric internalization assessment displaying time-dependent internalization of Hsp-70 Lf-ZF, Hsp-70 Ch-Lf-ZF and Hsp-70 Lf-PEG-ZF nanocomplexes in THP-1 cells and e Jurkat cells. Effective internalization was observed at 2 h Hsp-70 Lf-ZF nanocomplex post-treatment