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. 2016 Jan 16;17:35. doi: 10.1186/s12859-016-0885-0

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© Acuña et al. 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Simple representation of the notion of explanation. Left: A TRN representing 12 TF/BS affinity interactions between 9 genes. Costs 1, 3, and 9 are associated according to their p-values (k=3, r=3). Right: Six possible explanations for a co-expressed pair (F,I); two of them are optimal explanations (cost =10)