Fig. 4.
Conditioned place preference in incised rats. (A–C) Time spent in each chamber during the baseline and the test period in the Incision-Bupivacaine group (A), Incision-PBS group (B), and Sham Incision-Bupivacaine group (C). (D) The Difference Score for the drug-paired chamber. (E) The Difference Score for the PBS-paired chamber. (F) The Time Preference Score during the baseline and the test period. The results are expressed as mean and standard deviation. †P < 0.01 vs. Incision-PBS group; %P < 0.01 vs. Sham-Bupivacaine group, one-way ANOVA, followed by post-hoc Tukey’s multiple comparison test. ‡P < 0.001 vs. Incision-PBS group; #P < 0.001 vs. Sham-Bupivacaine group, two-way ANOVA with repeated measures on one factor, followed by post-hoc Bonferroni test. INC-Bup = Incision-bupivacaine group; INC-PBS = Incision-PBS group; Sham-Bup = Sham Incision-Bupivacaine group.