Skip to main content
. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Prenat Diagn. 2015 Sep 20;35(12):1218–1222. doi: 10.1002/pd.4681

Figure 1.

Figure 1

Trophoblast retrieval and isolation from the cervix (TRIC) isolates trophoblast cells from the cervix of ongoing pregnancies. Collection of cervical specimens is performed in an identical fashion as a pap smear, using a cytobrush and placing the specimen into a ThinPrep fixative. At the laboratory, isolation of the trophoblast cells (red) from the cervical cells (blue) is accomplished by incubating the cervical sample with nanoparticles bound to anti-HLA-G. The specimen is placed in a magnetic separator while the non-bound cervical cells are aspirated from the bound trophoblast cells.