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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Eur J Neurosci. 2015 Nov;42(10):2792–2804. doi: 10.1111/ejn.13094

Figure 1. Effect of ANA12+PB on the total seizure burden at P7 and P10 I.

Figure 1

Schematics of the experimental design. Experimental paradigm for the acute ligation surgery and synchronous video-EEG recordings with the time-course of drug administrations and the durations for each procedure. Arrowheads indicate time-points of drug administration after carotid-ligation and brain-harvesting for 24h WB data. II. A–D. Total time spent seizing on EEG was quantitated as seizure burden at P7 and P10 over a 3h period, and was represented by bar graphs (black bar=baseline, gray=2nd h, and white = 3rd h) A&C) vehicle (5% DMSO) and ANA12-alone treatment groups. The data from A&C were pooled to form a ligate-control group represented in B&D. B&D) ligate control vs. ANA12+PB+BTN. Within-group comparison was done using repeated measures ANOVA (i.e., *=P<0.05; **=P<0.01; ***=P<0.001). Brackets (@) denote significant between-group comparisons at each hour (independent sample t-tests; P<0.05).