. Author manuscript; available in PMC: 2017 Jan 1.

Published in final edited form as: J Pathol. 2015 Sep 15;238(1):21–30. doi: 10.1002/path.4599

Table 1.

Mouse ovarian tumor formation, progression and survival of mice with conditional knockout of Apc, Pten, and Arid1a

Genotype	Tumor formation (n/N) ^*	Metastasis (n/N)	Median survival (days)
Apc^fl/fl;Pten^fl/fl	18/18	0/18	64.5
Apc^fl/fl;Pten^fl/fl;Arid1a^fl/+	28/28	5/28	86.5
Apc^fl/fl;Pten^fl/fl;Arid1a^fl/fl	15/15	9/15	74.5

			Euthanized (weeks)

Apc^fl/+;Pten^fl/fl;Arid1a^fl/fl	3/8		40
Apc^fl/fl;Pten^fl/+;Arid1a^fl/fl	2/7	1/7	40
Apc^fl/fl;Pten^fl/+;Arid1a^fl/+	2/9		40
Apc^fl/+;Pten^fl/fl;Arid1a^fl/+	2/8	1/8	40
Apc^fl/+;Pten^fl/+;Arid1a^fl/fl	2/5		40
Apc^fl/+;Pten^fl/+;Arid1a^fl/+	0/4		40
Apc^fl/+;Pten^fl/fl	1/20	1/20	60
Apc^fl/fl;Pten^fl/+	0/20		60

n: number of mice that formed tumors or metastases;

N: total number of mice evaluated