Table 2.

Race-specific hazard ratio (HR) and area under receiver operating characteristic curve (AUC) for prediction of venous thromboembolism (VTE) during follow-up, ARIC

Outcome Model	Whites (n = 9,520)		African Americans (n = 3,049)
	HR (95% CI)*	AUC (95% CI)	HR (95% CI)*	AUC (95% CI)
Total VTE
All follow-up
Weighted GRS	1.41 (1.27, 1.56)	--	1.14 (0.94, 1.38)
Nonweighted GRS	1.22 (1.12, 1.32)	--	1.02 (0.90, 1.16)
First 20 years, 20-yr risk
Weighted GRS	1.47 (1.31, 1.66)	0.59 (0.56, 0.63)	1.06 (0.85, 1.32)	0.56 (0.51, 0.61)
Nonweighted GRS	1.24 (1.13, 1.36)	0.57 (0.54, 0.61)	0.98 (0.85, 1.14)	0.56 (0.51, 0.61)
Nongenetic factors†		0.64 (0.61, 0.67)		0.66 (0.61, 0.70)
Nongenetic + weighted GRS		0.67 (0.64, 0.70)		0.66 (0.62, 0.70)
Unprovoked VTE
All follow-up
Weighted GRS	1.65 (1.40, 1.93)	--	1.25 (0.92, 1.69)
Nonweighted GRS	1.33 (1.16, 1.51)	--	1.03 (0.84, 1.27)
First 20 years, 20-yr risk
Weighted GRS	1.81 (1.52, 2.16)	0.65 (0.60, 0.71)	1.13 (0.80, 1.59)	0.61 (0.54, 0.68)
Nonweighted GRS	1.41 (1.21, 1.64)	0.62 (0.56, 0.67)	0.96 (0.77, 1.21)	0.60 (0.53, 0.68)
Nongenetic factors†		0.67 (0.62, 0.72)		0.67 (0.60, 0.74)
Nongenetic + weighted GRS		0.72 (0.68, 0.77)		0.67 (0.60, 0.74)

^*HR per 1 allele increase in 5-SNP genetic risk score (GRS). HR for African Americans adjusted for 10 principal components of ancestry.

^†Nongenetic factors include: age (continuous), sex/HRT (men, women not on HRT, women on HRT), BMI (continuous), diabetes (yes, no), and history of cancer (yes, no) at baseline.