Table 3.
Hazard ratios and 95% confidence intervals for the association between cumulative average physical activity during premenopausal and postmenopausal periods and incident epithelial ovarian cancer in Nurses’ Health Study (1986–2010) and Nurses’ Health Study II (1989–2011)
| Physical activity in MET-hours/week, HR (95% CI) | |||||
|---|---|---|---|---|---|
| <3 | 3 – <9 | 9 – <18 | 18 – <27 | ≥27 | |
| Premenopausal physical activity | |||||
| All cases (N=462) | |||||
| Cases, n | 74 | 100 | 120 | 60 | 108 |
| Age-adjusted | 1.31 (0.97, 1.78) | 1.00 (ref) | 1.24 (0.95, 1.61) | 1.07 (0.77, 1.47) | 1.48 (1.12, 1.95) |
| Multivariable1 | 1.30 (0.96, 1.76) | 1.00 (ref) | 1.23 (0.94, 1.60) | 1.04 (0.76, 1.44) | 1.43 (1.09, 1.89) |
| Multivariable + BMI | 1.29 (0.95, 1.75) | 1.00 (ref) | 1.24 (0.95, 1.63) | 1.06 (0.77, 1.47) | 1.50 (1.13, 1.97) |
| Premenopausal cases (N=209) | |||||
| Cases, n | 30 | 42 | 52 | 26 | 59 |
| Age-adjusted | 1.35 (0.84, 2.18) | 1.00 (ref) | 1.19 (0.79, 1.79) | 1.03 (0.63, 1.68) | 1.60 (1.07, 2.39) |
| Multivariable2 | 1.34 (0.83, 2.16) | 1.00 (ref) | 1.16 (0.77, 1.75) | 0.99 (0.61, 1.62) | 1.51 (1.01, 2.26) |
| Multivariable + BMI | 1.32 (0.81, 2.12) | 1.00 (ref) | 1.19 (0.79, 1.80) | 1.04 (0.64, 1.71) | 1.66 (1.11, 2.49) |
| Postmenopausal cases (N=253) | |||||
| Cases, n | 44 | 58 | 68 | 34 | 49 |
| Age-adjusted | 1.29 (0.87, 1.92) | 1.00 (ref) | 1.29 (0.90, 1.84) | 1.14 (0.74, 1.75) | 1.38 (0.93, 2.03) |
| Multivariable3 | 1.26 (0.85, 1.88) | 1.00 (ref) | 1.28 (0.90, 1.83) | 1.10 (0.72, 1.69) | 1.35 (0.92, 1.99) |
| Multivariable + BMI | 1.25 (0.84, 1.86) | 1.00 (ref) | 1.28 (0.89, 1.82) | 1.09 (0.71, 1.68) | 1.34 (0.91, 1.99) |
| Postmenopausal physical activity | |||||
| Postmenopausal cases (N=574) | |||||
| Cases, n | 77 | 138 | 148 | 101 | 110 |
| Age-adjusted | 1.07 (0.80, 1.41) | 1.00 (ref) | 1.02 (0.81, 1.29) | 1.20 (0.93, 1.56) | 1.04 (0.81, 1.34) |
| Multivariable3 | 1.07 (0.81, 1.42) | 1.00 (ref) | 1.01 (0.80, 1.28) | 1.18 (0.91, 1.53) | 1.03 (0.80, 1.33) |
| Multivariable + BMI | 1.05 (0.79, 1.40) | 1.00 (ref) | 1.02 (0.80, 1.28) | 1.18 (0.91, 1.53) | 1.03 (0.80, 1.33) |
Stratified by age, calendar years and cohort, and adjusted for menopausal status at ovarian cancer diagnosis, duration of OC use, parity, history of tubal ligation, history of hysterectomy, duration of PMH use by type, family history of breast or ovarian cancer, cumulative average intake of lactose and caffeine
Accounted for the variables in 1 except menopausal status at ovarian cancer diagnosis and duration of PMH use by type
Accounted for the variables in 1 except menopausal status at ovarian cancer diagnosis