Figure 3. WT BMM injection in MK2^−/− mice restores some cytokine production, but not neoplasm development.

BMM injections into WT and MK2^−/− mice led to A) increased neoplasm development for WT mice, but not MK2^−/− with AOM/DSS treatments. In organ culture, B) IL-1α, C) IL-1β, D) IL-6, E) TNF-α, F) GM-CSF, and G) MCP-1 production were found at higher levels in WT mice, but were also increased in MK2^−/− mice supplemented with WT macrophages. N=6 for BMM supplementation experiments in duplicate experiments.