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Significantly greater decline in α6β2* nAChRs in all striatal areas in monkeys treated with MPTP 3-4× compared to 1-2× times. Autoradiograms are shown in A and the quantitative data in B. The dotted horizontal line and grey bar represent the mean ± SEM of α6β2* nAChR levels in unlesioned monkeys (n=5). Significantly different from MPTP 1-2×, #P < 0.05 using two-way ANOVA. *P < 0.05, **P < 0.01, main effect of lesioning between MPTP 1-2× compared to MPTP 3-4× group.
