Fig. 4. Top EVC Positions for LacI/GalR.
The top 20 consensus EVC positions (17, 27, 29, 51, 52, 55, 57, 98, 102, 117, 125, 150, 157, 160, 161, 193, 220, 291, 293, and 321; spacefilled black) for the LacI/GalR family were mapped onto the homodimeric structure of LacI (PDB: 1efa53). The DNA (ribbon at top of structure) and the bound allosteric effector ligand, (orthonitrophenyl-β-D-fucopyranoside, spacefilled white) are highlighted to show binding sites.