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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Microcirculation. 2015 Nov;22(8):724–736. doi: 10.1111/micc.12247

Figure 3. LV angiogenesis does not occur during CH-PH induced RV remodeling.

Figure 3

In (A), representative images of LV/septum stained with markers specific for endothelial cell glycoproteins (isolectin IB4) and myocyte plasma membrane glycoproteins (wheat germ agglutinin; WGA) are shown. IB4 stains endothelial cells of capillaries and larger resistance vessels (arrow), though only the former were quantified. Bar = 10 µm. Images were used for stereological assessment in animals exposed to normoxia (Norm) and chronic hypoxia (CH) for 1 −3 weeks. There was no change in LV cardiomyocyte volume (B), total LV capillary length, surface area, or lumen volume (C) after 1 week of normoxia (open bars) or chronic hypoxia (filled bars); 3 week data are not shown. Results obtained from 5 animals/group. P-values are for Student’s t-test.