Table 5.

RV hypoxia gene expression profile.

CH Time	Gene	Name	Genbank	Fold Δ	P
7 days	Ier3	Immediate early response 3	NM_133662	1.86	0.048
21 days	Anxa2	Annexin A2	NM_007585	1.66	0.039
	Bhlhe40	Basic helix-loop-helix family, member e40	NM_011498	2.44	0.013
	Bnip3	BCL2/adenovirus E1B interacting protein 3	NM_009760	2.59	0.021
	Btg1	B-cell translocation gene 1, anti-proliferative	NM_007569	1.79	0.007
	Ccng2	Cyclin G2	NM_007635	1.58	0.001
	Egln1	EGL nine homolog 1 (C. elegans)	NM_053207	1.62	0.017
	Ldha	Lactate dehydrogenase A	NM_010699	1.59	0.007
	Lgals3	Lectin, galactose binding, soluble 3	NM_010705	2.54	0.041
	Lox	Lysyl oxidase	NM_010728	1.54	0.002
	Map3k1	Mitogen-activated protein kinase kinase kinase 1	NM_011945	1.57	0.022
	Ndrg1	N-myc downstream regulated gene 1	NM_008681	1.61	0.027
	P4ha1	Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide	NM_011030	1.75	0.015
	Per1	Period homolog 1 (Drosophila)	NM_011065	2.02	0.012
	Pfkp	Phosphofructokinase, platelet	NM_019703	2.01	0.003
	Pkm	Pyruvate kinase, muscle	NM_011099	2.05	0.017
	Slc2a1	Solute carrier family 2 (facilitated glucose transporter), member 1	NM_011400	1.60	0.000
	Trp53	Transformation related protein 53	NM_011640	1.64	0.034

Changes in hypoxia- controls is shown after 7 or 21 days. Only genes whose expression was changed >1.5 fold are shown. Only a single hypoxia-dependent gene was upregulated after 7 days of CH-PH (out of 84 possible), while 17 hypoxia-dependent genes were upregulated after 21 days of CH-PH. Genes in bold were upregulated in an RV-specific manner (LV data not shown). N= 3 mice/group.