Table 2.
Cox regression hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between blood levels of organochlorines and mortality in the LIBCSP women diagnosed with breast cancer in 1996–1997 (n=633).
| 5-Year All-Cause Mortality |
5-Year Breast Cancer Specific-Mortality |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Age- Adjusteda |
Multivariable- Adjustedb |
Age- Adjusteda |
Multivariable- Adjustedb |
|||||||
| Deaths | Censored | HR (95% CI) | HR (95% CI) | p-trend | Deaths | Censored | HR (95% CI) | HR (95% CI) | p-trend | |
| p,p’-DDTc | ||||||||||
| Tertile 1 | 10 | 197 | 1 (Reference) | 1 (Reference) | 6 | 201 | 1 (Reference) | 1 (Reference) | ||
| Tertile 2 | 22 | 186 | 2.24 (1.06, 4.73) | 2.55 (1.20, 5.45) | 15 | 193 | 2.53 (0.98, 6.51) | 2.94 (1.12, 7.67) | ||
| Tertile 3 | 22 | 185 | 2.19 (1.03, 4.64) | 2.19 (1.02, 4.67) | 0.02 | 15 | 192 | 2.65 (1.03, 6.86) | 2.72 (1.04, 7.13) | 0.02 |
| p,p’-DDEd | ||||||||||
| Tertile 1 | 17 | 193 | 1 (Reference) | 1 (Reference) | 12 | 198 | 1 (Reference) | 1 (Reference) | ||
| Tertile 2 | 19 | 192 | 0.98 (0.50, 1.92) | 0.95 (0.48, 1.89) | 13 | 198 | 1.14 (0.51, 2.54) | 1.10 (0.48, 2.52) | ||
| Tertile 3 | 19 | 192 | 0.85 (0.41, 1.78) | 0.72 (0.33, 1.56) | 0.78 | 11 | 200 | 1.04 (0.42, 2.61) | 0.85 (0.32, 2.23) | 0.38 |
| Chlordanee | ||||||||||
| Tertile 1 | 13 | 182 | 1 (Reference) | 1 (Reference) | 9 | 186 | 1 (Reference) | 1 (Reference) | ||
| Tertile 2 | 19 | 177 | 1.40 (0.69, 2.87) | 1.26 (0.61, 2.61) | 13 | 183 | 1.59 (0.67, 3.76) | 1.53 (0.63, 3.69) | ||
| Tertile 3 | 19 | 176 | 1.34 (0.63, 2.86) | 1.26 (0.58, 2.71) | 0.13 | 12 | 183 | 1.70 (0.67, 4.33) | 1.68 (0.65, 4.35) | 0.13 |
| 15-Year All-Cause Mortality |
15-Year Breast Cancer Specific-Mortality |
|||||||||
| Age- Adjusteda |
Multivariable- Adjustedb |
Age- Adjusteda |
Multivariable- Adjustedb |
|||||||
| Deaths | Censored | HR (95% CI) | HR (95% CI) | p-trend | Deaths | Censored | HR (95% CI) | HR (95% CI) | p-trend | |
| p,p’-DDTc | ||||||||||
| Tertile 1 | 56 | 151 | 1 (Reference) | 1 (Reference) | 21 | 186 | 1 (Reference) | 1 (Reference) | ||
| Tertile 2 | 69 | 139 | 1.28 (0.90, 1.82) | 1.42 (0.99, 2.06) | 29 | 179 | 1.43 (0.81, 2.50) | 1.59 (0.90, 2.83) | ||
| Tertile 3 | 61 | 146 | 0.98 (0.68, 1.41) | 0.99 (0.68, 1.44) | 0.70 | 24 | 183 | 1.20 (0.67, 2.15) | 1.23 (0.68, 2.24) | 0.30 |
| p,p’-DDEd | ||||||||||
| Tertile 1 | 54 | 156 | 1 (Reference) | 1 (Reference) | 28 | 182 | 1 (Reference) | 1 (Reference) | ||
| Tertile 2 | 58 | 153 | 0.84 (0.57, 1.22) | 0.81 (0.56, 1.19) | 25 | 186 | 0.90 (0.52, 1.57) | 0.92 (0.53, 1.62) | ||
| Tertile 3 | 77 | 134 | 0.79 (0.54, 1.18) | 0.66 (0.44, 0.99) | 0.10 | 21 | 190 | 0.78 (0.41, 1.47) | 0.70 (0.36, 1.37) | 0.43 |
| Chlordanee | ||||||||||
| Tertile 1 | 40 | 155 | 1 (Reference) | 1 (Reference) | 20 | 175 | 1 (Reference) | 1 (Reference) | ||
| Tertile 2 | 68 | 128 | 1.48 (1.00, 2.20) | 1.42 (0.94, 2.12) | 27 | 169 | 1.46 (0.81, 2.62) | 1.47 (0.81, 2.67) | ||
| Tertile 3 | 70 | 125 | 1.23 (0.81, 1.87) | 1.31 (0.86, 2.00) | 0.07 | 24 | 171 | 1.43 (0.75, 2.72) | 1.45 (0.76, 2.75) | 0.35 |
Long Island Breast Cancer Study Project (LIBCSP) participants diagnosed with breast cancer between August 1, 1996 and July 31, 1997 and followed-up through December 31, 2011.
Adjusted for age at diagnosis
Adjusted for age at diagnosis, smoking status, income, body mass index, and parity/lactation history
Lipid-adjusted p,p’-DDT concentration cut-points: Tertile 1 (<56.8ng/g), Tertile 2 (≥56.8–<91.2ng/g), Tertile 3 (≥91.2ng/g)
Lipid-adjusted p,p’-DDE concentration cut-points: Tertile 1 (<467.1ng/g), Tertile 2 (≥467.1–<1,058.2ng/g), Tertile 3 (≥1,058.2ng/g)
Lipid-adjusted chlordane (Σoxychlordane and trans-nonachlor) concentration cut-points: Tertile 1 (<81.1ng/g), Tertile 2 (≥81.1–<131.0ng/g), Tertile 3 (≥131.0ng/g)