Table 3.
Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between blood levels of organochlorines and mortality in the LIBCSP women diagnosed with breast cancer in 1996–1997 (n=625), stratified by BMI.
| BMI <25kg/m2 |
15-Year All-Cause Mortality |
15-Year Breast Cancer Specific-Mortality |
||||||
|---|---|---|---|---|---|---|---|---|
| Multivariable-Adjusteda | Multivariable-Adjusteda | |||||||
| Deaths | Censored | HR (95% CI) | p-trend | Deaths | Censored | HR (95% CI) | p-trend | |
| p,p’-DDTb | ||||||||
| Tertile 1 | 16 | 78 | 1 (Reference) | 8 | 86 | 1 (Reference) | ||
| Tertile 2 | 29 | 71 | 2.32 (1.23, 4.38) | 12 | 88 | 1.92 (0.76, 4.88) | ||
| Tertile 3 | 20 | 65 | 1.43 (0.73, 2.79) | 0.19 | 9 | 76 | 1.46 (0.55, 3.89) | 0.56 |
| p,p’-DDEc | ||||||||
| Tertile 1 | 25 | 96 | 1 (Reference) | 15 | 106 | 1 (Reference) | ||
| Tertile 2 | 23 | 73 | 0.72 (0.39, 1.33) | 11 | 85 | 0.82 (0.34, 1.99) | ||
| Tertile 3 | 18 | 48 | 0.53 (0.24, 1.14) | 0.26 | 3 | 63 | 0.23 (0.05, 1.09) | 0.18 |
| Chlordaned | ||||||||
| Tertile 1 | 15 | 84 | 1 (Reference) | 6 | 93 | 1 (Reference) | ||
| Tertile 2 | 26 | 65 | 1.79 (0.92, 3.47) | 15 | 76 | 2.93 (1.10, 7.79) | ||
| Tertile 3 | 20 | 51 | 1.42 (0.69, 2.92) | 0.27 | 17 | 64 | 1.72 (0.54, 5.48) | 0.57 |
|
BMI ≥25kg/m2 |
15-Year All-Cause Mortality |
15-Year Breast Cancer Specific-Mortality |
||||||
| Multivariable-Adjusteda | Multivariable-Adjusteda | |||||||
| Deaths | Censored | HR (95% CI) | p-trend | Deaths | Censored | HR (95% CI) | p-trend | |
| p,p’-DDTb | ||||||||
| Tertile 1 | 39 | 73 | 1 (Reference) | 13 | 99 | 1 (Reference) | ||
| Tertile 2 | 40 | 63 | 1.10 (0.69, 1.75) | 17 | 86 | 1.51 (0.71, 3.19) | ||
| Tertile 3 | 40 | 80 | 0.73 (0.46, 1.17) | 0.47 | 15 | 105 | 1.11 (0.51, 2.41) | 0.37 |
| p,p’-DDEc | ||||||||
| Tertile 1 | 29 | 59 | 1 (Reference) | 13 | 75 | 1 (Reference) | ||
| Tertile 2 | 35 | 77 | 0.77 (0.46, 1.29) | 14 | 98 | 0.98 (0.45, 2.14) | ||
| Tertile 3 | 57 | 84 | 0.67 (0.40, 1.11) | 0.14 | 18 | 123 | 0.93 (0.42, 2.08) | 0.98 |
| Chlordaned | ||||||||
| Tertile 1 | 25 | 71 | 1 (Reference) | 14 | 82 | 1 (Reference) | ||
| Tertile 2 | 40 | 62 | 1.13 (0.66, 1.94) | 12 | 90 | 0.94 (0.41, 2.14) | ||
| Tertile 3 | 50 | 70 | 1.09 (0.63, 1.89) | 0.24 | 17 | 103 | 1.36 (0.60, 3.08) | 0.47 |
Long Island Breast Cancer Study Project (LIBCSP) participants diagnosed with breast cancer between August 1, 1996 and July 31, 1997 and followed-up through December 31, 2011.
Adjusted for age at diagnosis, smoking status, income and parity/lactation history
Adjusted for age at diagnosis, smoking status, income, body mass index, and parity/lactation history
Lipid-adjusted p,p’-DDT concentration cut-points: Tertile 1 (<56.8ng/g), Tertile 2 (≥56.8–<91.2ng/g), Tertile 3 (≥91.2ng/g)
Lipid-adjusted p,p’-DDE concentration cut-points: Tertile 1 (<467.1ng/g), Tertile 2 (≥467.1–<1,058.2ng/g), Tertile 3 (≥1,058.2ng/g)
Lipid-adjusted chlordane (Σoxychlordane and trans-nonachlor) concentration cut-points: Tertile 1 (<81.1ng/g), Tertile 2 (≥81.1–<131.0ng/g), Tertile 3 (≥131.0ng/g)