Anterior hippocampal seed connectivity differences in APOEɛ4 carriers and noncarriers during encoding. During encoding, significant differences in anterior hippocampus connectivity between APOEɛ4 carriers and noncarriers were found in right precuneus (blue), right anterior insula (pink) as well as right middle cingulate cortex (green). The peak coordinate for each cluster is reported in Montreal Neurological Institute (MNI) space, in x, y, z planes (mm). For illustration of the direction and magnitude of the difference between groups, contrasts of parameter estimates from each cluster are plotted by group in boxplots. The band within the box represents the median while the upper and lower edges of the box represent the first and third quartiles, respectively. The whiskers extend up to 1.5 times the interquartile range. Data points outside this range are plotted as outliers.