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. Author manuscript; available in PMC: 2016 Nov 16.
Published in final edited form as: Angew Chem Int Ed Engl. 2015 Aug 28;54(47):13985–13988. doi: 10.1002/anie.201507047

Scheme 1.

Scheme 1

Identification of viral genomes from an environmental sample. a) Viruses are encapsulated into drops. b) After thermo-cycling, amplicons are generated in the drops containing the target virus. c) Drops are sorted based on their fluorescence intensities. d) The enriched virus solution is treated with USER to digest amplicons followed by whole genome amplification. e) The amplified products are sequenced and assembled using our computational pipeline.