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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Allergy Clin Immunol. 2015 Jul 17;137(1):179–187.e10. doi: 10.1016/j.jaci.2015.06.002

Figure 3. Somatic hypermutation (SHM) rate.

Figure 3

Isoform-specific V(D)J clones analyzed in adult KMT2DMut/+ patients(circles) and age-matched adult controls (triangles). Presented as percent (%) divergent from germline IGH sequence. (A,B, C) IgM, IgG and IgA mutations rates in KMT2DMut/+ patients and controls. IgG mutation rates (B) were significantly lower in 3 of 4 KMT2DMut/+ patients than in controls (*p < 0.05). All data (A,B, C) are present as mean ± standard deviation of the mean.