Table 2.

SNPs with association P-values <0.01 for the four RhinoGen phenotypes showing an enrichment of small p-values. Beta coefficients are shown for three qualitative traits and odds ratio for the one quantitative trait.

Gene	SNP	Chr	Alleles (min/maj)	Effect allele	RhinoGen Phenotype	P value	Beta coeff	Odds ratio (OR)	Lower 95% CI	Upper 95% CI
DDX58	rs10738889	9	G/A	A	Viral loss of asthma control	0.0099		0.5097	0.2879	0.8750
DDX58	rs10738891	9	T/G	G	Weeks infected	0.0068	0.6158		0.2163	1.0152
DDX58	rs11795343	9	C/T	T	Weeks infected	0.0076	−0.5780		−0.7530	−0.2015
DDX58	rs11795343	9	C/T	T	Viral loss of asthma control	0.0020		0.4243	0.2370	0.7297
DDX58	rs17289402	9	A/G	G	Viral loss of asthma control	0.0014		5.2311	1.6722	23.2345
DDX58	rs3205166	9	G/T	T	Weeks infected	0.0029	−0.6637		−1.0507	−0.2766
DDX58	rs3205166	9	G/T	T	Viral loss of asthma control	0.0046		0.4540	0.2585	0.7719
DDX58	rs6476362	9	C/T	T	Viral loss of asthma control	0.0067		0.3873	0.1861	0.7669
DDX58	rs7034650	9	G/A	A	Weeks infected	0.0074	−0.8616		−1.4358	−0.2873
DDX58	rs944581	9	C/G	G	Weeks infected	0.0073	0.5856		0.1928	0.9783
EIF2AK2	rs4233920	2	A/G	G	Weeks infected	0.0008	1.4456		0.4795	2.4116
IFNB1	rs10435777	9	A/T	T	Cold symptom burden	0.0014	−10.882		−16.814	−4.9498
IFNB1	rs7849713	9	C/G	G	Cold symptom burden	0.0014	−10.882		−16.814	−4.9498
IL21	rs2221903	4	C/T	T	Weeks infected	0.0056	−0.6582		−1.0724	−0.2441
IL28A	rs11671087	19	C/T	T	Cold symptom burden	0.0084	−5.9473		−10.705	−1.1890
IL8	rs2227306	4	C/T	T	Cold symptom burden	0.0097	−5.0177		−8.9301	−1.1053
IL8	rs2227306	4	C/T	T	Viral loss of asthma control	0.0036		0.4368	0.2392	0.7650
JAK2	rs6476939	9	A/T	T	Number of illnesses	0.0099	−0.4496		−0.7658	−0.1334
JAK2	rs6476939	9	A/T	T	Cold symptom burden	0.0061	−5.7245		−9.5868	−1.8622
MX1	rs459498	21	A/G	G	Weeks infected	0.0011	−0.6561		−1.0422	−0.2699
MX1	rs467593	21	G/A	A	Weeks infected	0.0111	−0.6896		−1.1686	−0.2106
SCGB1A1	rs2509973	11	A/C	C	Cold symptom burden	0.0018	6.3144		2.4981	10.1307
STAT1	rs11887698	2	G/A	A	Number of illnesses	0.0070	−0.5265		−0.9697	−0.0833
STAT4	rs16833215	2	G/A	A	Number of illnesses	0.0085	−0.4957		−0.8408	−0.1506
STAT4	rs16833249	2	C/T	T	Number of illnesses	0.0049	−0.5064		−0.8218	−0.1910
STAT4	rs6434435	2	A/G	G	Number of illnesses	0.0122	−0.5584		−0.9715	−0.1453
VDR	rs12721370	12	A/C	C	Weeks infected	0.0105	1.0124		0.2930	1.7318
VDR	rs4328262	12	G/T	T	Cold symptom burden	0.0055	−6.2878		−10.376	−2.1996
VDR	rs4328262	12	G/T	T	Viral loss of asthma control	0.0059		0.4045	0.2039	0.7601
VDR	rs7139166	12	C/G	G	Viral loss of asthma control	0.0064		2.3272	1.2885	4.4188