Table 3.

Genes and SNPs associated with variation in viral illness response, asthma, and wheezing phenotypes in the RhinoGen discovery population, the COPSAC replication population, and COAST validation population (P ≤0.05 highlighted in bold font).

					RhinoGen P values											COPSAC P values	COAST P values
Gene	SNP	Location	Chr	Alleles (minor/major)	MAF	Number of illnesses	Number of viral illnesses	Weeks infected	Cold symptom burden	Viral cold symptom burden	Asthma symptom burden	Viral asthma symptom burden	Asthma	Loss of asthma control	Viral loss of asthma control	Asthma exacerbations	Asthma (at age 6)	RSV wheezing illness (first 3 years of life)	RV wheezing illness (first 3 years of life)	Wheezing illness (first 3 years of life)
DDX58	rs10738889	intron	9	G/A	0.40	0.261	0.312	0.116	0.225	0.319	0.753	0.453	0.896	0.010	0.010	0.660	0.558	0.065	0.128	0.038
DDX58	rs3205166	coding	9	G/T	0.36	0.223	0.177	0.003	0.228	0.259	0.295	0.177	0.926	0.022	0.005	0.910	0.011	0.208	0.090	0.012
DDX58	rs9695310	intron	9	C/G	0.47	0.109	0.948	0.744	0.324	0.108	0.770	0.589	1.000	0.015	0.073	0.367	0.015	0.126	0.810	0.482
DDX58	rs6476362	intron	9	C/T	0.21	0.314	0.678	0.289	0.948	0.798	0.183	0.115	0.826	0.008	0.007	0.718	0.061	0.147	0.288	0.023
DDX58	rs11795343	intron	9	C/T	0.43	0.136	0.212	0.008	0.411	0.436	0.065	0.035	0.590	0.005	0.002	0.576	0.012	0.824	0.177	0.090
DDX58	rs10813831	coding	9	A/G	0.27	0.388	0.942	0.296	0.642	0.509	0.034	0.022	0.919	0.005	0.014	0.292	0.035	0.396	0.762	0.207
EIF2AK2	rs2373114	intron	2	T/C	0.09	0.030	0.042	0.082	0.043	0.045	0.958	0.358	0.275	0.298	0.327	0.849	0.125	0.987	0.006	0.590
JAK2	rs913594	intron	9	A/G	0.28	0.018	0.185	0.429	0.065	0.203	0.420	0.353	0.393	0.962	0.788	0.415	0.027	0.035	0.018	0.036
JAK2	rs3780375	intron	9	A/G	0.23	0.019	0.066	0.205	0.042	0.127	0.350	0.321	0.597	0.507	0.737	0.827	0.012	0.021	0.029	0.012
JAK2	rs3780379	intron	9	A/G	0.18	0.028	0.090	0.266	0.015	0.059	0.397	0.387	0.992	0.684	0.917	0.403	0.041	0.083	0.089	0.081
MX1	rs469390	coding	21	G/A	0.39	0.912	0.385	0.141	0.182	0.171	0.191	0.031	0.823	0.423	0.766	0.001	0.590	0.848	0.770	0.668
MX1	rs2070229	coding	21	C/T	0.26	0.567	0.922	0.032	0.260	0.158	0.265	0.050	0.493	0.816	0.568	0.009	0.531	0.067	0.016	0.184
MX1	rs467593	intron	21	G/A	0.31	0.909	0.549	0.011	0.599	0.421	0.055	0.016	0.823	0.978	0.634	0.047	0.149	0.136	0.066	0.456
STAT4	rs16833215	intron	2	G/A	0.31	0.008	0.023	0.574	0.251	0.344	0.842	0.554	0.920	0.689	0.920	0.474	0.882	0.984	0.042	0.381
STAT4	rs6434435	intron	2	A/G	0.17	0.012	0.319	0.221	0.584	0.356	0.991	0.807	0.905	0.576	0.719	0.754	0.020	0.815	0.220	0.970
STAT4	rs7566274	intron	2	C/A	0.41	0.030	0.031	0.388	0.877	0.661	0.673	0.318	0.178	0.316	0.211	0.712	0.818	0.045	0.488	0.627
STAT4	rs11685878	intron	2	T/C	0.43	0.965	0.203	0.878	0.148	0.094	0.433	0.318	0.046	0.664	0.397	N/A	0.215	0.001	0.279	0.048
STAT4	rs4853546	intron	2	A/G	0.37	0.457	0.212	0.974	0.265	0.280	0.433	0.560	0.031	0.308	0.164	0.024	0.720	0.001	0.958	0.141
STAT4	rs7574070	intron	2	A/C	0.39	0.946	0.188	0.566	0.089	0.045	0.212	0.143	0.385	0.340	0.228	0.147	0.034	0.001	0.312	0.023
VDR	rs12721370	intron	12	A/C	0.09	0.392	0.318	0.010	0.433	0.655	0.762	0.993	0.838	0.831	0.679	0.206	0.010	0.825	0.553	0.454
VDR	rs4328262	intron	12	G/T	0.40	0.018	0.046	0.445	0.005	0.009	0.016	0.047	0.269	0.002	0.006	0.973	0.021	0.892	0.338	0.964