Table II.
Association of differentially expressed genes in NSAID-related LTP-induced anaphylaxis (NSAID-LTP-A) patients with Diseases and Disorders, Canonical pathways and Networks.
| NSAID-LTP-A- Diseases and Disorders | P-value | Num. Molec. | Top Disease/Function Annotation | |||
|---|---|---|---|---|---|---|
| Cancer | 0.03-3.4×10-9 | 445 | Adenocarcinoma; carcinoma; epithelial neoplasia; abdominal neoplasm; abdominal cancer; breast or colorectal cancer; gastrointestinal adenocarcinoma; colorectal adenocarcinoma | |||
| Gastrointestinal Disease | 0.03-5.7×10-7 | 232 | ||||
| NSAID-LTP-A -Top Canonical Pathways | P-value | Ratio | Molecules up- or downregulated in pathway | |||
| Death Receptor Signaling | 0.0067 | 0.088 | ↑DIABLO, ↓PARP15, ↑ACTA2, ↑APAF1, ↓ TNFSF10, ↓BIRC3, ↓PARP9, ↓XIAP | |||
| The Visual Cycle (and Retinoate biosynthesis I) | ↓ | 0.0098 (0.04) | 0.2 (0.1) | DHRS9, RDH5, RBP5 | ||
| Sonic Hedgehog Signaling | ↓ | 0.0112 | 0.138 | PRKACB, PTCH1, GLI1, DYRK1A | ||
| ERK5 Signaling | ↓ | 0.0123 | 0.095 | IL6ST, MEF2A, GNAQ, FOSL1, WNK1, ELK4 | ||
| p53 Signaling | ↓ | 0.0186 | 0.072 | PIK3R3, HDAC9, MDM4, PLAGL1, APAF1, BRCA1, SERPINE2 | ||
| NSAID-LTP-A - Top Networks | Score | Molecules in pathway | ||||
| Cell Morphology, Embryonic Development, Connective Tissue Disorders | 40 | 30 | ||||
| Cell Death and Survival, Embryonic Development, Renal Necrosis/Cell Death | 33 | 27 | ||||
| Cell Movement, Cardiov. System Development anci Function, Organ Morphology | 29 | 25 | ||||
| Cell-To-Cell Signaling and Interaction, Organismal Development, Cell Morphology | 26 | 23 | ||||
Shown are the most significant identified pathways/networks. Arrows indicate the predicted state of activation for the pathway considering the changes in the majority genes involved.