Table III.
Association of differentially expressed genes in LTP-induced anaphylaxis (LTP-A) patients with Diseases and Disorders, Canonical pathways and Networks.
| LTP-A- Diseases and Disorders | P-value | Num. Molec. | Top Disease/Function Annotation | |||
|---|---|---|---|---|---|---|
| Cancer | 0.03-1×10-13 | 1305 | Adenocarcinoma; gastrointestinal adenocarcinoma; colorectal adenocarcinoma; transcription of RNA (↓); colorectal carcinoma; epithelial neoplasia; transcription (↓); colon adenocarcinoma | |||
| Gastrointestinal Disease | 0.03-1×10-12 | 654 | ||||
| LTP-A- Top Canonical Pathways | P value | Ratio | Molecules up- or downregulated in pathway | |||
| B Cell Receptor Signaling | ↓ | 0.00001 | 0.187 | BLNK, PTK2B, PIK3R1, ABL1, PDPK1, PTPRC, PTK2, PAX5, IKBKB, CAMK2D, CFL2, CD22, AKT3, MAP3K2, ATM, ETS1, MAP3K9, CD19, PIK3C2A, MAPK8, IKBKE, ATF2, SYNJ2, PIK3R3, EBF1, RRAS2, INPP5F, VAV3, NFATC2, MEF2C, INPP5K, ELK1 | ||
| Molecular Mechanisms of Cancer | ↓ | 0.00049 | 0.136 | TGFBR1, ARHGEF7, SMAD3, ADCY4, PIK3R1, ABL1, BRAF, PTK2, E2F6, ITGA3, CAMK2D, RHOU, E2F5, AKT3, PLCB1, CASP8, BRCA1, SMAD1, BIRC3, RASA1, TAB1, ATM, ITGA4, CASP10, LRP5, CCNE2, PIK3C2A, PTCH1, GNAQ, PRKAR2A, SMAD7, MAPK8, APAF1, XIAP, APC, PIK3R3, RASGRF2, RRAS2, MAX, RASGRP1, IRS1, GNAT2, RBPJ, LEF1, ELK1, GLI1, ARHGEF9, BCL2L11, CTNND1 | ||
| Sphingosine-1-phosphate Signaling | ↓ | 0.00022 | 0.194 | ASAH2B, PIK3C2A, PTK2B, PIK3R1, ACER2, ADCY4, GNAQ, PLCL2, PDGFC, PDGFB, PIK3R3, PTK2, SMPD4, CASP2, CASP1, RHOU, PLCB1, AKT3, CASP8, ATM, CASP10 | ||
| PI3K Signaling in B Lymphocytes | ↓ | 0.00021 | 0.187 | BLNK, IL4R, CD19, PIK3R1, ABL1, PDPK1, IKBKE, ITPR1, PLCL2, ATF2, PTPRC, IKBKB, TLR4, RRAS2, CAMK2D, VAV3, IRS1, PLCB1, AKT3, NFATC2, PLEKHA1, ELK1, CR2 | ||
| Top Networks | Score | Molecules in pathway | ||||
| Cancer, Dermatological Diseases and Conditions, Tumor Morphology | 35 | 35 | ||||
| Gene Expression, Cancer, Gastrontestinal Disease | 33 | 34 | ||||
| Cell Signaling, Hereditary Disorcer, Inflammatory Disease | 31 | 33 | ||||
| Carbohydrate Metabolism, Lipid Metabolism, Small Molecue Biochemistry | 29 | 32 | ||||
Shown are the most significant identified pathways/networks. Arrows indicate the predicted state of activation for the pathway considering the changes in the majority genes involved.