Table IV.
Increased expression of neutrophil-related genes in LTP-anaphylaxis (LTP-A) patients. Genes are sorted by fold change
| Gene | Protein name | p-value | Fold Change |
|---|---|---|---|
| CD177 | CD177 molecule | 0.0289 | 4.69 |
| LTF | Lactotransferrin | 0.0037 | 4.309 |
| PRTN3 | Proteinase 3 | 0.0303 | 4.191 |
| SCO2 | SCO2 cytochrome c oxidase assembly protein | 0.0047 | 4.144 |
| OLFM4 | Olfactomedin 4 | 0.0308 | 4.089 |
| LCN2 | Lipocalin 2 | 0.0073 | 3.928 |
| DEFA4 | Defensin, alpha 4, corticostatin | 0.0125 | 3.920 |
| DEFA1 | Defensin, alpha 1 | 0.0196 | 3.627 |
| IFI6 | Interferon, alpha-inducible protein 6 | 0.0039 | 3.531 |
| MMP8 | Matrix metallopeptidase 8 (neutrophil collagenase) | 0.0247 | 3.447 |
| ELANE | Elastase, neutrophil expressed | 0.0149 | 3.033 |
| CAMP | Cathelicidin antimicrobial peptide | 0.0014 | 2.847 |
| AZU1 | Azurocidin 1 | 0.0180 | 2.768 |
| RETN | Resistin | 0.0054 | 2.570 |
| FCGR1 | Fc fragment of IgG, high affinity 1B or C), receptor (CD64) | 0.0164 | 2.442 |
| MX1 | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 0.0037 | 2.345 |
| CEACAM8 | Carcinoembryonic antigen-related cell adhesion molecule 8 | 0.0311 | 2.270 |
| CEACAM6 | Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0442 | 2.192 |
| TYROBP (DP12) | TYRO protein tyrosine kinase binding protein | 0.0005 | 2.182 |
| GSR | Glutathione reductase | 0.0048 | 2.124 |
| VNN2 | Vanin 2 | 0.0004 | 2.083 |
| ARG1 | Arginase | 0.0229 | 2.064 |
Note: Ingenuity Pathway Analysis using the genes shown above indicated that the top Network association representing their functional connection was Infectious Disease, Cellular Movement and Immune Cell Trafficking.