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5-hydroxymethycytosine (5-hmC) immunolabeling is markedly attenuated in both primary and metastatic melanoma when compared with melanocytic nevi. The mean immunohistochemical staining score ± standard deviation for nevi, primary invasive melanoma and metastatic melanoma are shown for both cohorts. *p < 0.001 (two-sided Student’s t-test). n.s., not statistically significant.
