Table 1.

IC₅₀ values (μM) of compounds 1 - 22.

Compound	Rhodesain	T. brucei	Hep G2a
1	0.89 ± 0.10	5.80 ± 1.00	84.71 ± 5.79
2	2.15 ± 0.11	> 20	83.42 ± 9.16
3	1.78 ± 0.20	> 20	92.20 ± 2.07
4	> 20	19.32 ± 0.06	92.67 ± 6.48
5	3.04 ± 0.11	> 20	62.54 ± 1.94
6	2.41 ± 0.11	20.02 ± 0.40	86.31 ± 4.80
7	> 20	2.83 ± 0.26	86.19 ± 9.67
8	1.10 ± 0.10	> 20	97.18 ± 4.67
9	3.38 ± 0.12	18.31 ± 0.52	98.14 ± 6.06
10	> 20	12.93 ± 0.29	80.78 ± 7.91
11	2.36 ± 0.11	> 20	109.00 ± 5.33
12	> 20	> 20	86.97 ± 3.62
13	> 20	9.81 ± 0.81	88.35 ± 6.52
14	0.56 ± 0.10	11.79 ± 1.51	62.09 ± 7.92
15	> 20	> 20	74.01 ± 1.24
16	> 20	> 20	40.20 ± 10.98
17	> 20	> 20	86.49 ± 9.96
18	> 20	> 20	65.53 ± 8.64
19	> 20	14.75 ± 0.15	81.79 ± 10.71
20	> 20	17.06 ± 0.29	88.83 ± 13.35
21	> 20	17.49 ± 1.71	99.72 ± 5.96
22	0.47 ± 0.10	1.93b	5.37c

^aPercent Viability at 20 μM;

^bMacdonald et al. [11],

^cGold et al. [12].