Table V.

Multivariate correlations (coefficient and p value) between iron indices (ln scale), clinical history and laboratory values.

	Liver		Pancreas		Renal		Spleen
Independent variable*	Coeff	P	Coeff.	P	Coeff.	P	Coeff.	P
Age (years)	0.04	0.047					-0.04	0.47
SBP (mm Hg)							0.01	0.32
DBP (mm Hg)			0.003	0.34			0.02	0.15
Years of transfusion therapy							0.14	0.06
Currently on chelation (yes/no)					-0.30	0.12
Deferasirox in past year (yes/no)	-0.39	0.07
Deferoxamine in past year (yes/no)	0.21	0.50
Haemoglobin at enrolment (g/l)					-0.22	0.02	-0.23	0.18
Average pre-treatment haemoglobin over last 6 months, g/l					-0.06	0.51
Absolute reticulocyte count (× 109/l)					-0.0006	0.32	0.0004	0.60
Serum Iron (μg/l)	0.0002	<0.001	0.00001	0.40			0.0001	0.08
Total Iron Binding Capacity (μmol/l)	-0.0006	0.04			-0.001	0.006
Transferrin saturation (%)	0.006	0.07
Lactate dehydrogenase (u/l)	-0.0005	0.04			0.001	<0.001
C-reactive protein (mg/l)							0.03	0.15
Alanine transaminase (u/l)	0.001	0.26
Creatinine (μmol/l)					-0.92	0.09
Bilirubin (μmol/l)	-0.04	0.31			0.02	0.59
eGFR (ml/min/1.73m2)					-0.0003	0.57
MRI vasculopathy score (1-5)			0.006	0.72	0.17	0.15	-0.06	0.80
Platelet count (×109/l)							0.002	0.06
White blood cell count (×109/l)	-0.002	0.92	0.007	0.38
Spleen volume (ml)			-0.0002	0.13
Spleen coarse echo texture (yes/no)	0.08	0.49
Model r2	0.59	<0.0001	0.08	0.29	0.44	<0.0001	0.38	0.003
Adjusted r2	0.52		0.02		0.38		0.26
In model including “Spleen present”:
Spleen present					-0.32	0.07
Model r2					0.49	<0.0001
Adjusted r2					0.41

Coeff., coefficient; SBP, systolic blood pressure; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; MRI, magnetic resonance imaging

^*Variables are included in the multivariate model if the univariate p value <0.10.