Table 4.

Nonclassical targets for members of the PRL family

Biological Targets	Ligands (function)	References
Endothelial cells	PLF (angiogenic) PLF-RP (anti-angiogenic) 16kDa-PRL (anti-angiogenic)	104, 112–115
Hematopoietic precursors	PLP-E and PLP-F (promote erythrocyte and megakaryocyte development)	105–107
Natural killer cells	PLP-A (modulator of the uterine natural killer cell phenotype)	108, 109
Eosinophils	Decidual PRP (unknown)	71
Hepatocytes	PLP-C, PLP-N (unknown)	S. Ohboshi, J. Bustamante, M.J. Soares, unpublished results