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. 2015 Aug 28;36(12):4847–4858. doi: 10.1002/hbm.22954

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© 2015 Wiley Periodicals, Inc.

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Mediation analysis. Independent factor was rs405509 variants, dependent variables were SDMT scores and the mediator was the nodal efficiency of the left PCC. Path a shows coefficient for the effect of genotype on the nodal efficiency of left PCC. Path b shows the coefficient for the effect of the nodal efficiency of left PCC on SDMT. Paths c and c′show coefficients for the total (yellow) and direct (blue) effects of genotype on SDMT, respectively. The nodal efficiency of the left PCC in the WM structural network mediated the effect of rs405509 variants on SDMT. All coefficients standardized. Sobel test was performed for mediation analysis (Z = 2.01, P = 0.045). [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]