Table 2.

Burden test results for the ten most significant genes

Chr	Gene	Pos first SNP	Pos last SNP	V0.05	S_MAF	β	P	βa	Pa
2	SLC19A3	228,552,234	228,563,911	3	0.054	−0.266	5.85E-06	−0.166	2.77E-03
11	MADD	47,296,533	47,315,499	2	0.054	−0.254	2.00E-05	−0.169	2.85E-03
11	C11orf82	82,625,814	82,644,904	4	0.080	−0.208	3.08E-05	−0.105	2.71E-02
11	KDELC2	108,352,777	108,357,137	2	0.054	−0.241	5.24E-05	−0.219	5.21E-04
12	LRRK2	40,619,082	40,758,652	4	0.054	−0.223	2.84E-04	−0.133	2.09E-02
14	SLC8A3	70,527,576	70,634,200	3	0.071	−0.196	2.56E-04	−0.049	3.68E-01
14	SLC24A4	92,909,807	92,959,940	5	0.063	−0.177	5.30E-06	−0.288	1.00E-04
15	STARD9	42,930,972	43,011,009	8	0.080	−0.109	3.11E-04	−0.053	3.45E-01
19	GRIN3B	1,000,785	1,009,585	3	0.063	−0.190	9.00E-05	−0.119	3.47E-02
19	LENG8	54,966,557	54,968,038	3	0.063	−0.202	2.35E-04	−0.112	3.52E-02

V0.05 = SNPs with MAF<0.05; S_MAF= Sum of the V0.05 minor allele frequencies; β= Effect size not adjusted for APOE; P= P-value not adjusted for APOE.

^aAnalysis that adjusts for APOE. All analyses were based on N=56 subjects.