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Transcriptional effects of exogenous murine EGF (mEGF) on selected Module 1 nodes during SIRS. mEGF administered to mice exposed to MV+SA significantly down-regulated several key immuno-inflammatory genes (Tnfa, Tlr2, Tlr4), implying that targeting the EGF-EGFR axis in Module 2 influences the transcriptional response of Module 1. Data represent mean relative expression ± SEM. P-values for differences between means were calculated using two-tailed Student’s t-test. *P ≤ 0.05.
