Table 1.
Summary of literature references of allelic association of 5-HTT promoter with risk of alcohol use problems
| Reference | Population | Co-occurring clinical feature | Mean age (years) | Male (%) | Sample size | Risk allele | Type of study |
|---|---|---|---|---|---|---|---|
| Gelernter et al. (1997)) | European ancestry | – | – | 77.8 | 274 | – | Population based |
| Edenberg et al. (1998) | European ancestry | – | – | – | 131 | No bias | Family based |
| Sander et al. (1998) | German | High severity alcoholism | 39.04 | – | 531 | SS | Population based |
| Hallikainen et al. (1999) | Finnish | Type II alcoholism | 43.91 | 100 | 105 | S | Gender based |
| Hammoumi et al. (1999) | French | 43.61 | 71.6 | 140 | – | – | |
| Schuckit et al. (1999) | European Ancestry | 100 | 41 | LL | Gender based | ||
| Ishiguro et al. (1999) | Japanese | Early onset | 52.24 | 92.2 | 166 | L | Population based |
| Gorwood et al. (2000) | French | Suicidality | 43.61 | – | 171 | S allele unrelated to alcoholism | Population based, alcohol dependent |
| Thompson et al. (2000) | European ancestry | Tourette syndrome | – | – | 256 | No bias | Population based |
| Lichtermann et al. (2000) | German, Hungarian | – | – | 82.6 | 102 | S | Family based study |
| Matsushita et al. (2001) | Japanese | – | 50.5 | 100 | 962 | SS | |
| Preuss et al. (2000) | German, Hungarian | Suicidality | 41.02 | 80.4 | 280 | S | Population based |
| Pastorelli et al. (2001) | Italian | Liver cirrhosis | – | 60 | No bias | Population based | |
| Kranzler et al. (2002) | European ancestry | Early onset | – | 74.9 | 555 | No bias | Population based |
| Kranzler et al. (2002) | African-American | Early onset | – | 75.0 | 151 | No bias | Population based |
| Stoltenberg et al. (2002) | Caucasian | Antisocial | – | 100 | 44 | No bias | Family based association |
| Johann et al. (2003) | German | ADHD | 43.1 | 83.4 | 534 | – | – |
| Nellissery et al. (2003) | European ancestry | Depression | 41.05 | 59.5 | 556 | – | – |
| Nellissery et al. (2003) | African-American | Depression | 38.85 | 43.8 | 59 | – | – |
| Konishi et al. (2004) | Mexican-American | 38.24 | 100 | 451 | – | – | |
| Mannelli et al. (2005) | African-American | Cocaine abuse | 36.29 | 70 | 1411 | S | Population based |
| Herman et al. (2005) | Caucasian | – | – | 0 | 412 | S | Gender based |
| Olsson et al. (2005) | Australian | – | Range (14–24) | – | – | L | Population based |
| Kweon et al. (2005) | Korean | – | – | – | – | L | Population based |
| Skowronek et al. (2006) | German | – | 15 | 48 | 305 | LL | Population and gender effects |
| Kohnke et al. (2006) | German | – | – | – | 215 | No association | Population based |
| Gokturk et al. (2008) | Caucasian | Anxiety /depression | Range (18–75) | 0 | 110 | LL | Gender based |
| Pombo et al. (2008) | Portuguese | – | – | – | 97 | LL | Population based |
| Pinto et al. (2008) | – | – | – | – | 48 | S | |
| Lin et al. (2007) | Han Chinese | Depression | 40 | 100 | 133 | SS | Population based |
| Saiz et al. (2009) | Caucasian/Spanish | – | 47.8 | 84.8 | 165 | NS | Population based |
| Dawes et al. (2009) | Mixed races (Whites, Hispanics, Biracial, American Indians) | – | 18.7 | 62 | 21 | LL | – |
| Rasmussen et al. (2009) | – | – | 69.2 | 0 | 1365 | No Significance | Gender based |
| van der Zwaluw et al. (2010) | Dutch Caucasian | – | 13.4 | 48 | 428 | S | Population based |
| Merenakk et al. (2011) | Estonian | – | Range (9–18) | – | 583 | SS | Longitudinal study |
| Wang et al. (2011) | Yunnan Han Chinese | – | – | – | 118 | S | Population based |
| Enoch et al. (2011) | African-American | – | 34 | 100 | 360 | S | Population based |