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. 2016 Jan 16;16:25. doi: 10.1186/s12885-015-2029-8

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© Kampa-Schittenhelm et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Flow cytometric apoptosis assay measuring early apoptotic (annexin V) and later phase apoptotic cells (propidium iodide) after exposure of Jurkat (a-c) or MOLM13 (d-f) cells to THC. Dose-effect curves for Jurkat (a) and MOLM13 (d) cells treated with THC in a dose-dependent manner are shown. Student’s t-test demonstrates significance (p < 0.05) of induction of apoptosis at 46 μM (Jurkat), resp. 32 μM (MOLM13). Experiments were performed in triplicates. Non-linear regression analysis was performed to compute IC_50s (b, e). Flow cytometry raw data are shown for Jurkat (c) and MOLM13 (f) cells demonstrating overwhelming induction of apoptosis in the highest tested doses – with no effect for methanol as drug carrier at the highest tested dose