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. 2016 Jan 16;16:25. doi: 10.1186/s12885-015-2029-8

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© Kampa-Schittenhelm et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Expression of CB1 and CB2 in acute leukemia. a FACS flow cytometry based analysis of intracellular (CB1/2 perm) and extracellular CB expression levels in MOLM and Jurkat cell lines. b Western immunoblotting expression analysis of CB1 and CB2 in Jurkat and MOLM leukemia cell lines. The major isoform of CB1 (1a long) has a molecular weight of 52 KDa. CB2 is expected at 40-50 KDa. c Exracellular CB1/CB2 expression levels of native leukemia cells (n = 12) and comparatively bone marrow donors (n = 10) and the Jurkat and MOM13 cell lines as assessed by flow cytometry. The responder/nonresponder cohort (n = 4, resp. n = 8) contains patient samples responsive/non-responsive towards THC ex vivo. (*-****) statistical significance at p < 0.05 (Student’s t-test)