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. 2016 Jan 16;16:25. doi: 10.1186/s12885-015-2029-8

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© Kampa-Schittenhelm et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Proapoptotic effect of THC is mediated via CB1 and CB2. a The CB1 antagonist LY320135 and a selective CB2 inverse ligand agonist (JTE-907) were tested in dose-dependent dilution series. Dose-effect plots from an apoptosis annexin V-based flow cytometry assay are shown. b MOLM13 and Jurkat cells were pretreated with either antagonist (LY, LY320135; JTE, JTE-907) for 12 h and THC was administered for another 48 h (30 μM for Jurkat and 45 μM for MOLM13 cells). Induction of apoptosis was analyzed as described above. (*-****) statistical significance at p < 0.05 (Student’s t-test). c Western immunoblotting of cleaved caspase 3 in response to THC +/- preexposition to LY320135 or JTE-907 is shown.