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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: Cancer Res. 2015 Dec 30;76(2):206–215. doi: 10.1158/0008-5472.CAN-15-0295

Figure 1.

Figure 1

Analysis of the missense BAP1 mutations identified in a population of asbestos-exposed malignant mesothelioma (MM) cases. A) Analysis performed using Protein Variation Effect Analyzer (PROVEAN), Sorting Intolerant from Tolerant (SIFT), and PolyPhen-2 software tools. B) Assessment of the degree of conservation across different vertebrate species at sites of three BAP1 missense mutations identified among MM cases. Note that two missense mutations sites, Asn78 and Arg383, are highly conserved, indicative of the importance of the amino acids at these sites.