Fig. 5. Tau Expression in AAV1 Tau^P301L Injected Mice.

(A) AAV1 tau^P301L injected brain section of a db homozygous mouse stained with PHF-1 primary antibody. Extensive tau pathology developed in the hippocampus of these mice at 6 months of age. (B) Extensive tau pathology could also be observed in the cortex. (C – F) Tau^P301L injected mice displayed extensive PHF1 immunoreactivity compared to uninjected controls (Top: PHF-1, Bottom: Nuclei stained with DAPI for anatomical reference). Note that no PHF1 immunoreactivity is observed in mice not injected with AAV1 tau^P301L (D).