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P53 alteration in BCC tumors as a function of increasing B haplotype blocks. The prevalence of p53 alteration (mutation or abnormal IHC) was calculated among individuals with varying numbers of KIR B haplotype blocks (summed across centromeric and telomeric blocks of the KIR locus). Those with p53 alterations were four times more likely to have KIR B then those with normal p53 (p<0.004); there was no evidence of a gene-dosage effect.
