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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: Clin Cancer Res. 2015 Aug 31;22(2):436–447. doi: 10.1158/1078-0432.CCR-15-1070

Figure 4. Expression of Multiple IRS on human T cells.

Figure 4

CD8, CD4, TCR+, and TCR− subsets of Ly95 TILs were analyzed to see the proportional makeup of TILs expressing single, double, triple, or no IRs compared to cryopreserved controls.

A) Expression profiles of injected CD8 and CD4 cells (cryo T cells) are compared to TILs. Both CD4 and CD8 TILs expressed more IRs than the cryo T cells.

B) Expression profiles of injected TCR+ and TCR negative cells (cryo T cells) are compared to TILs. TCR+ TILs had higher proportions of single IR, double IR, and triple IR TILs than TCR− TILs. Also, all TCR+ TILs has upregulation of at least one IR.